Sickle cell-spherocytosis associated with hemolytic anemia.

.H j \-I F:RCEI)Es V. h)E TomlaRd; ROSA , ANTON 10 ( )ltTmz .N 1) 1)n mn i.\ 1 R As I 1949, PaIllimig amid his asso(’iatesm demohistrated the existence of Rh abnormal hemoglohili ill the blood of persons suffering froni sickle (‘(‘11 anemia amid correlated its presence with the clinical picture. They showed that sickle cell hemoglobin had different electrophoretic mobility than normal hemoglobin. Subsequeiitly, other abnormal henioglobins (C,2 1), E,4 (,6 and H ) have i)een detected and differentiated by certain physicocheniicai properties. Various hemoglohimiopathies i ’ere found to he related to the inheritance of one or more of these abnormal hemoglobi ns. The patient to be reported had aneniia asso(’iat-ed with the rare comiul)ination of sickle (‘eli and spherocytosis. The clinical auud heniatologic dat-a pertaining to the case are presented, and the role played by ea(’h of the two intraem’yt.hrocytie defects imi the production of the heniolytic process is discussed.